| 24 Octobre 2016
The company’s report states that the US will not only remain the largest major market for  MDD drugs, but will extend its lead over other countries, primarily due  to the wide-ranging availability of treatments and the commercial  success of atypical antipsychotics, which generated 39% of the sales in  the US market in 2015. Christos Michaelides,  Ph.D., GlobalData’s Analyst covering Neurology and Ophthalmology,  explains: “As a class, atypical antipsychotics are due to retain their  market share during the forecast period and are expected to generate  sales of $1.9 billion in 2025, with a CAGR of 7.1%, which will represent  a little over two-fifths of the US MDD market. “The main driver behind  the success of atypical antipsychotics in the MDD market is the high  price for drugs in this class. While Abilify generated the greatest  revenue for the atypical antipsychotics in 2015, its sales will remain  static during the forecast period. This will be due to increasing use of  generic aripiprazole, and competition from Otsuka/Lundbeck’s Rexulti,  which is due to see its US sales increase rapidly to just under $588  million by 2025.” GlobalData estimates that  five products in the late-stage pipeline will enter the MDD market in  the US during the forecast period: Alkermes’ ALKS-5461, Allergan/Gedeon  Richter/Mitsubishi Tanabe’s Vraylar, Axsome Therapeutics’ AXS-05,  Janssen’s esketamine,  and Allergan’s rapastinel. By 2025, GlobalData expects that these  pipeline drugs will generate over $800 million, of which Janssen’s  esketamine will achieve the greatest share.
London – 24 October 2016 - The US market for major  depressive disorders (MDD) will rise from $2.4 billion in 2015 to $4.6  billion by 2025, at a strong compound annual growth rate (CAGR) of 6.6%,  according to research and consulting firm GlobalData.